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: Eli Lilly secures FDA approval for Foundayo (orforglipron), a once-daily oral GLP-1 pill for chronic weight management in adults with obesity or overweight with weight-related conditions

Limited permeability of intestinal epithelium: The tight junctions between intestinal epithelial cells limit the penetration of large molecule protein drugs, making it difficult for them to enter the bloodstream through the intestinal mucosa

24 This opens the door to exploring these novel compounds as potential therapeutic agents in a broader range of conditions

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